ANTI-PHOSPHO-HIST H3 (THR3) 100

Analysis Note

ControlAcid extract from colcemid-treated HeLa cells

Application

Anti-phospho-Histone H3 (Thr3) Antibody is a Rabbit Polyclonal Antibody for detection of phospho-Histone H3 (Thr3) also known as H3T3P, Histone H3 (phospho T3) & has been validated in IF, WB, ICC.

Research Sub CategoryHistones

Research CategoryEpigenetics & Nuclear Function

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the ′beads on a string′ structure. r> r>The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.

Immunogen

synthetic peptide containing, in which pT corresponds to phosphothreonine at position 3 of human Histone H3

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Physical form

Immunodepleted

Format: Unpurified

0.05% sodium azide and 30% glycerol.

Quality

routinely evaluated by immunoblot in acid extracted proteins from mitotic HeLa cells

Specificity

H3 phosphorylated at Thr3

Storage and Stability

2 years at -20°C

Target description

17 kDa